Development of a Leuko-Depletion Blood Filter

The main objectives of the project are: 

  • To develop a non-woven filter for removing leukocytes from blood and its components before blood transfusion.
  • To filtering the other impurities present in the blood components 

Normally, 7-8% of human body’s weight is from blood. This essential fluid carries out the critical functions of transporting oxygen and nutrients to our cells and getting rid of carbon dioxide, ammonia, and other waste products.  In addition, it plays a vital role in our immune system and in maintaining a relatively constant body temperature.  Blood is a highly specialized tissue composed of more than 4,000 different kinds of components.  Four of the most important ones are red cells, white cells, platelets, and plasma.  

Leukocytes are white blood cells, the body produces leukocytes to help fight off foreign substances in the body such as bacteria, viruses and abnormal cells in an effort to avoid sickness or disease.  However, when leukocytes are transfused into another person, with red blood cells, platelets or plasma, they are not well tolerated and have been associated with some types of transfusion reactions. Leuko-depletion is a process by which leucocytes are removed from donated blood. It has been estimated that the average content of leucocytes in donated human whole blood is 10/ unit.  By the current standards, the total content leucocytes in a blood unit should be less than 5 x 106/ unit after preparation and a minimum of 85% of whole blood or red cells is retained.

One of the methods used to remove leukocytes from blood components by use of textile fibre pads/non-woven.  Various fibre webs like cotton wool, cellulose acetate, nylon, nylon wool, polyester, micro denier polyester, micro denier glass fibre, etc. were used in leukocytes filters.  Presently, micro denier polyester, micro denier nylon, micro denier glass fibre made filters are commercially available in some foreign countries. 

In this project it is proposed to develop Leuko-depletion blood filter non-woven web using sub micro denier polyester fiber, sub micro denier nylon fiber or combination of both at non-woven web.