Development of textile matrices for the effective wound management
Principal goal in wound management is to achieve rapid wound closure with functional and aesthetic scar. According to the recent reports, wound healing generally begins with the initiation of four distinct but overlapping phases viz hemostasis, inflammation, proliferation and remodeling under normal conditions. Activation of these pathways determines the rate of healing of specific type of wounds.
However, this orderly progression of the healing process particularly angiogenesis of granulation phase is impaired in chronic wounds when it encounters with diabetes or arterial insufficiency. Angiogenesis, the formation of new blood vessels, is necessary for wound repair since the new vessels provide nutrients to support the active cells, promote granulation tissue formation and facilitate the clearance of debris. Approximately 60% of the granulation tissue mass is composed of blood vessels which also supply the necessary oxygen to stimulate repair and vessel growth.
The main objective of the project is to develop textile matrices by embroidery technology for the efficient incorporation of growth factor for the stimulation of angiogenesis in chronic wounds. It is planned to use platelet derived growth factor (PDGF) to induce blood vessel formation in the chronic wound patients.